Many adolescents take breath mints or chew gum because they feel insecure about how their breaths smell. This not only leaves a minty taste in one’s mouth but also a cooling sensation throughout.

Scientists at the Biophysical Society have delved deeper into this phenomenon. They discovered that cooling sensations are caused by the TRPM8 protein. 

Scientists have labeled the protein as a built-in thermometer. Specifically, the body detects cold temperatures through the TRPM8 protein channel, which is located at nerve endings.  As the atmospheric temperature drops, the protein triggers an electrical signal to be sent to the brain, producing a cold sensation. 

Mint creates the same feeling through a chemical called menthol, which activates an opening to TRPM8.

However, this chemical interaction does not necessarily cause humans to experience the cooling sensation. Instead, it is the ion channels of the brain that give rise to it. 

This discovery has significant implications for future medical treatments. For example, researchers at Duke University have highlighted the potential for improvements to therapeutic treatments for pain and inflammatory relief. 

Similarly, studies indexed in PubMed suggest that by blocking TRPM8 receptors can help reduce cold-related migraines.

Further research, highlighted in the Journal of Smooth Muscle Research, showcased that by targeting bladder sensitivity through channels, bladder overactivity and pain can be reduced without altering normal body temperatures

Studies featured in BMC Ophthalmology are currently investigating eye drops that target tear receptors to combat dry eye disorders.